Fig. 3: The somatic alteration patterns of YST primary tumors.
A Significantly mutated genes (SMGs) in all YST primary tumors (n = 24) except for those from patients P02 and P03, with gonadal dysgenesis. The bars on the top and the right show the mutational rate observed for each tumor and the composition of mutations in selected genes, respectively. Two known cancer driver genes are in bold, and three driver candidates were identified by both MuSiC2 and MutSigCV. B The comparison of TP53 missense mutation frequencies in YST and 33 TCGA cancer types. C Amplification and deletion signals identified in YST. The segmentation data from the 24 YST primary samples were pooled for GISTIC2 analysis. Significantly amplified (left panel) or deleted (right panel) peaks were identified at FDR = 10−3. The top and bottom numerical values refer to G-scores and q values, respectively. D The copy-number alteration frequencies of cancer drivers across primary YST samples.
