Fig. 4: Model of GTPase-mediated maturation of human mtLSU.
From: Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
Intermediate states of the mtLSU are depicted as surface with coloring as in Figs. 1–3. Models of immature and mature mtLSU were derived from previous studies (PDB 5OOM, 3J7Y)3,5. Closeup views illustrate GTPase-mediated rearrangements in the peptidyl transferase center (PTC). PTC intermediate states are depicted as in Fig. 2 and Supplementary Fig. 4, with the regions undergoing conformational changes highlighted in cyan.
