Table 2 MIC determined by LiofilchemĀ® MIC Test StripsTM.

From: Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

Strain

Description

5-FC MIC (µg/ml)

Strains containing gene deletion or substitution

H99 derived strains

Ā Ā 

H99

wild type

0.023–0.032

C1918

fcy1Ī”

>32

C1931

fcy2Ī”

>32

C1920

fur1Ī”

>32

32C12

CNAG_04784Ī”

0.032–0.047

41H10

nrg1Ī”

0.032–0.047

R265 derived strains

Ā Ā 

R265

wild type

0.064–0.094

C1960

fcy1Ī”

>32

C1911

fcy2Ī”

>32

C2178

fur1Ī”

>32

C2172

CNBG_2198Ī”

0.064–0.125

WM276 derived strains

Ā 

WM276

wild type

0.016–0.023

C1832

fcy1Ī”

>32

C1834

fcy2Ī”

>32

C1900

fur1Ī”

>32

C2022

44 transfers of C1900

>32

C2080

URA6V172L

0.19/0.38

C2171

DPB2G508C

0.012–0.016

Strains related to suppressor

Ā 

KN99 derived strains

Ā Ā 

KN99

wild type

0.032–0.047

13C2

uxs1Ī”

>32

C1952

47 transfers of 13C2

0.064–0.094

C2050

Knrg1 in 13C2

0.064–0.125

C2119

Kugd1 in 13C2

0.047

C2133

Knrg1 in KN99

0.032–0.047

C2168

Kugd1 in KN99

0.032–0.047

WM276 related strains

Ā 

C2053

uxs1Ī”

>32

C2074

UXS1 complemented

0.023

C2104

Wugd1 in uxs1Ī”

0.047–0.064

C2072

Wnrg1 in uxs1Ī”

>32

C2113

Xnrg1 in uxs1Ī”

>32

C2061

Wugd1 in WM276

0.012–0.023

C2151

Fcy2-mNG in WM276

0.032–0.047

C2152

Fcy2-mNG in uxs1Ī”

>32

C2153

Fcy2-mNG in uxs1Ī” + Wugd1

0.047–0.064

WL8 derived strains

Ā Ā 

WL8

WM276 derived

>32

C1933

51 transfers of WL8

0.016–0.023

C2028

BCK1R1382* in WL8

>32

C2143

Wugd1 in WL8

0.016–0.023

WL9 derived strains

Ā Ā 

WL9

WM276 derived

>32

C1943

51 transfers of WL9

0.032–0.047

C2029

RAN1Y45* in WL9

>32

C2030

Wugd1 in WL9

0.032–0.047

C2071

Wnrg1 in WL9

>32

C2111

Xnrg1 in WL9

>32