Fig. 6: The N-Myc cistrome is altered upon Rb1 loss. | Nature Communications

Fig. 6: The N-Myc cistrome is altered upon Rb1 loss.

From: Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

Fig. 6: The N-Myc cistrome is altered upon Rb1 loss.

a Venn diagram showing the overlap of N-Myc binding by ChIP-seq from PRN (n = 3) and PN (n = 2) tumors (peak cutoff: q < 0.0001). b Differential transcription factor motif enrichment between N-Myc binding sites in PRN and PN tumors. c Heatmaps of N-Myc binding in PRN and PN tumors at regions of accessible chromatin associated with neuroendocrine and luminal subpopulations by scATAC-seq in Fig. 5a. d N-Myc binding at indicated loci in PRN (n = 3) and PN (n = 2) tumors.

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