Fig. 8: TAAR enhancer 1 operates in cis.
From: Coordination of two enhancers drives expression of olfactory trace amine-associated receptors
a Schematic illustration of four different mouse genotypes by crossing heterozygous TAAR enhancer 1 knockout mice with heterozygous Taar2-9 cluster knockout mice. According to the assumption that TAAR enhancer 1 functions in cis, in trans, or in cis plus trans, the hypothetical percentage of positive cell numbers in different genotypes were indicated by normalizing to wild-type (genotype 1) mice (set as 100%). b Representative images of Taar2, Taar3, Taar5, and Taar6 expression in four different genotypes is indicated by using a single-color in situ hybridization. Scale bar = 25 μm. c The numbers of OSNs expressing Taar2, Taar3, Taar5, and Taar6 were quantified and the percentage of positive cell numbers normalized to wild type was plotted. Data are presented as mean values ± SEM (n = 9 for Taar2 detection, n = 8 for Taar3 detection, n = 8 for Taar5 detection, n = 10 for Taar6 detection). In c, *p < 0.05, **p < 0.01, ***p < 0.001, by one-way ANOVA and post hoc Tukey’s test.
