Fig. 4: Comparison of HFB response onset by anatomical location during task anticipation.

A Histogram showing the distribution of response onset latency (ROL) of HFB at the frontal operculum, the anterior insula, the posterior insula, and visual regions. Each observation represents the ROL of HFB at the single-trial level calculated for all trials across all subjects (palatable and taste-neutral conditions). The vertical line denotes the median ROL time. B Schematic representing the sequence of HFB activity onset: early visual response to cue with the subsequent delay in activation of the frontal operculum, followed by involvement of anterior insula and subsequently posterior insula.