Table 1 Effect of reaction parameters.
From: Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
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|---|---|---|---|
Entry | Variation from standard conditions | Yield (%) | ee (%) |
1 | None | 85 | 94 |
2 | 25°C, instead of 10°C | 83 | 90 |
3 | Ni(acac)2, instead of NiBr2·glyme | 6 | - |
4 | as entry 3, but plus 1.5 equiv NaBr | 62 | 88 |
5 | Boc2O, instead of DMDC | 14 | 93 |
6 | DMBP, instead of PC | 0 | - |
7 | No NH4Cl | 54 | 93 |
8 | No Ni, or no PC, or no light | 0 | - |
9 | C1–C4, instead of (acid+DMDC + NH4Cl) | as shown below | |
10 | L1–L5, instead of (S)-L | as shown below | |
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