Fig. 1: Study setup and pharmacokinetics.
a Schema of study flow with timepoints of ITPP administration and assessments. b Dose-escalation schema with single, weekly, and total doses for different cohorts. c Boxplots displaying median plasma concentrations at start of infusion (hour 0), 3 and 6 h as wells as 30 min, 1 and 2 h after end of intravenous ITPP administration (hour 8) of increasing doses in cohorts on treatment days. Upper and lower ends of boxplots represent 25th and 75th quartiles. Whiskers extend to values within 1.5 * IQR from the boxplot, with data beyond plotted separately as outliers (n = 3–4 patients per cohort with 1 measurement performed in technical duplicates per timepoint for each treatment day (normally 9) per patient).
