Fig. 4: Tissue-based hypoxia response markers of one exemplary patient. | Nature Communications

Fig. 4: Tissue-based hypoxia response markers of one exemplary patient.

From: Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

Fig. 4

a Histological images taken at 20x magnification of the sample taken before ITPP treatment (left hemi-hepatectomy) compared to the sample obtained after ITPP (microwave ablation). Note the decreased expression of hypoxia-mediated genes such as CA9 and SLC2A1 after ITPP treatment and signs of increased vessel maturity by increased EGR expression. Scale bare: 200 μm. N = 1 patient. Histological quantifications are shown as boxplots displaying mean values ± standard deviation and overlaid single measurements. Statistical differences derived from two-sided students t-test with no adjustment for multiple comparisons. **p < 0.01, ***p ≤ 0.001, NS. = No significant difference.

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