Fig. 1: Maximum likelihood tree based on core genome SNPs of 813 Neisseria gonorrhoeae strains collected from 2005 to 2017 in the United States, including clade/fastbaps cluster, year, and sex of sex partner. | Nature Communications

Fig. 1: Maximum likelihood tree based on core genome SNPs of 813 Neisseria gonorrhoeae strains collected from 2005 to 2017 in the United States, including clade/fastbaps cluster, year, and sex of sex partner.

From: Phylogenomic analysis reveals persistence of gonococcal strains with reduced-susceptibility to extended-spectrum cephalosporins and mosaic penA-34

Fig. 1: Maximum likelihood tree based on core genome SNPs of 813 Neisseria gonorrhoeae strains collected from 2005 to 2017 in the United States, including clade/fastbaps cluster, year, and sex of sex partner.

MSW men that have sex with women, MSM men that have sex with men, MSMW men that have sex with men and women, HHS Health and Human Services region, MIC minimum inhibitory concentration with respect to azithromycin (AZM), ciprofloxacin (CIP), penicillin (PEN), tetracycline (TET), cefixime (CFM), and ceftriaxone (CRO). Highlighted clades contain isolates where we identified the majority of elevated cephalosporin MICs. The tree also includes several reference genomes: FA19 (root, ǂ), international MLST ST1903 strains possessing the mosaic penA-60 allele (*) including strains from Japan (FC428, FC460) and Canada (47707); WHO reference strains WHO-X (H041, Japan) and WHO-Z (A8806, Australia) marked by (ɤ); and WHO-Y (F89, France) marked by (⁂). A summary of antimicrobial susceptibility to each respective antibiotic is shown with colors: susceptible (light orange), elevated MIC range (teal), or high-level MICs (dark green). Alleles for penA are colored based on their amino acid sequence homology to penA-34 (≥98% is a derivative allele; teal), differing mosaic penA allele (dark green), or absence of a mosaic penA allele.

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