Fig. 6: Plasma glycomic and metabolic markers that distinguish post-treatment controllers (PTCs) from non-controllers (NCs).
From: Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
Pre-ATI levels of three glycan structures are lower in PTCs compared to NCs: (a) the disialylated glycans, A2, in the IgG glycome, (b) the highly sialylated glycan structure (A3G3S3), and (c) T/Tn antigen (measured as binding to ABA lectin). Pre-ATI levels of four glycan structures were higher in PTCs compared to NCs: (d) total fucose (binding to AAL lectin) in plasma, (e, f) core fucose (binding to LCA and PSA lectins) in plasma, and (g, h) (GlcNAc)n (binding to STL and UDA lectins). Pre-ATI levels of two metabolites were higher in PTCs compared to NCs: (i) α-ketoglutaric acid and (j) l-glutamic acid. All statistical comparisons were performed using a two-sided Mann–Whitney test. Truncated violin plots showing median. False Discovery Rate (FDR) was calculated using Benjamini–Hochberg (BH) method to correct for multiple comparison in panels (a–f) and nominal P values are reported in panels (g, h). Source data are provided as a Source Data file.
