Table 1 Model description for the PRS models presented in the manuscript.
From: Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Model Name | Model description |
|---|---|
ORS.full | PRS including SNPs with a pT ≤ 1e-5 |
ORS.no.APOE | PRS including SNPs with a pT ≤ 1e-5 and excluding SNPs in the APOE region (chr19:44.4-46.5 Mb) |
PRS.full | PRS including SNPs with a pT ≤ 0.1 (unless otherwise specified) |
PRS.no.APOE | PRS including SNPs with a pT ≤ 0.1 and excluding SNPs in the APOE region (chr19:44.4-46.5 Mb) (unless otherwise specified) |
PRS.AD | PRS calculated as a weighted sum of PRS.no.APOE (including SNPs with a pT ≤ 0.1, unless otherwise specified) and APOE(ε2 + ε4), where APOE effects were weighted with effect sizes (B(ε2) = −0.47 and B(ε4) = 1.12) as in Kunkle et al. 2019 |
