Fig. 6: A proposed Alb-hHv1 structural model from molecular dynamics simulations. | Nature Communications

Fig. 6: A proposed Alb-hHv1 structural model from molecular dynamics simulations.

From: Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils

Fig. 6

a The Alb-hHv1 complex in two orientations showing the three Alb domains DI (gray), DII (orange) and DIII (wheat) and the two subunits (cyan and blue) of a dimeric hHv1 channel. The horizontal gray lines indicate the position of the membrane boundary. b Close-up view of the interaction interface between Alb and two individual hHv1 subunits in two binding sites in the structural model. Left, interaction Site 1, H193 of hHv1 subunit A (cyan) may form direct interaction with Alb residue H288 and the adjacent E188 and E192. Right, interaction Site 2, H193 of hHv1 subunit B (blue) may form direct interaction with Alb residue H338 and the adjacent Y334, R337, and F374.

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