Fig. 1: Overall structure of human ABCA4.
From: Structural basis of substrate recognition and translocation by human ABCA4
a Topological diagram of ABCA4. TMD: transmembrane domain; ECD, extracellular domain; NBD, nucleotide-binding domain; R1 and R2, regulatory domains; IH, intracellular helices; EH, extracellular helices. b Overall structure of ABCA4. The two halves of ABCA4 are colored marine and green for half 1 (TMD1, ECD1, NBD1 and RD1) and half 2 (TMD2, ECD2, NBD2 and RD2), respectively. Two phospholipid molecules bound between TMD1 and TMD2 in the cytoplasmic membrane leaflet are shown as gray sticks. The N-linked glycans are displayed as black sticks. All structural figures were prepared using PyMol (https://www. pymol.org/) or UCSF Chimera65.
