Fig. 5: ATR-deleted neurons are more excitable.
From: ATR regulates neuronal activity by modulating presynaptic firing
a Schematic representation of hippocampal electrophysiology measurements on lateral perforant pathway (LPP)-dentate gyrus granule cell synapses. b Rheobase current of 1st provoked action potential by increasing stimulation in control (Ctr) and ATR-FBΔ (FBΔ) neurons. Box plot indicates the median (middle line), whiskers as max value (top) and min value (bottom) and hinges as 25 percentile (top) and 75 percentile (bottom). MWU test (unpaired, two-tailed), p = 0.007. **p < 0.01. c Number of action potentials (AP) in granule cells of the dentate gyrus in control (n = 10) and ATR-FBΔ neurons (n = 10) after 1000 ms current stimulation steps of 0 to 200 pA. Error bars indicate SEM. 2-way ANOVA with Holm-Sidak Post Hoc Analysis. ***p < 0.001. d Schematic representation of analysis on AP properties. e AP amplitudes within 20 Hz AP train. Error bars indicate SEM. 2-way ANOVA with Holm-Sidak Post Hoc Analysis. ***p < 0.001. f Plot of half-height width of AP in whole-cell recorded dentate gyrus granule cells within the 20 Hz train stimulation. Error bars indicate SEM. 2-way ANOVA with Holm-Sidak Post Hoc Analysis. ***p < 0.001. b, c, e, f The number of neurons measured is indicated within the graph. Source data are provided as a Source Data file.
