Fig. 7: ATR deletion in neurons does not cause activation of the DDR.
From: ATR regulates neuronal activity by modulating presynaptic firing
a Western blot analysis of the hippocampus of 3-month-old control (Ctr) and ATR-FBΔ (FBΔ) mice for indicated proteins. The DDR activation is controlled by HCT116 cells without (−) or with (+) tBHP for 15 min. GAPDH serves as loading control. Four mice (numbers on the top of lanes) of the indicated genotypes were analyzed. b Immunostaining of ATR-PCΔ cerebellum with antibodies against Calbindin (for PCs) and γH2AX (DNA damage marker, white arrows). The γH2AX signal is controlled by the cortical sections of mice after 4 Gy ionizing irradiation (IR). The images are representative from 3 to 4 mice per genotype analyzed. Source data are provided as a Source Data file.
