Fig. 5: Antibody responses against SARS-CoV-2 S1 protein and neutralization of FIN-25 by age and gender.

A BNT162b2 vaccinated health care workers (initially seronegative, n = 169) were divided into four age groups. Age specific differences of anti-S1 IgG antibody levels and neutralization titres against FIN-25 virus isolate were analyzed. Sera was collected three weeks (3w) and six weeks (6wk) after the first vaccine dose. Differences between age groups were tested with two-tailed Mann–Whitney U test. Two-tailed p-values < 0.05 were considered significant. Exact p-values were **=0.0078, ***=0.0007, and ****<0.0001 for 3wk EIA, **=0.0021 (age group 35–44 vs. 55–65), *= 0.0.231, and **=0.0041 for 6wk EIA, and *=0.0133 and ***=0.0005 for 3wk MNT. B Gender-specific differences in S1 specific IgG antibody responses and neutralization titres against FIN-25 were analyzed. Differences between age and gender groups were tested with two-tailed Mann–Whitney U test. Two-tailed p-values <0.05were considered significant. Exact p-values were *=0.0412. The data in A and B are presented as geometric means and geometric SDs. Neutralization titres <20 were plotted as 10.