Fig. 2: Association of polygenic risk score and TGCT status.
From: Identification of 22 susceptibility loci associated with testicular germ cell tumors
Polygenic risk scores (PRS) were calculated for independent samples from n = 5602 men with TGCT and 5006 men without disease from a model incorporating the 22 novel and 56 previously identified markers and effect size estimates from the meta-analysis. Odds ratios are relative to the median risk, composed of subjects in 45–55th percentile of PRS. Men in the top 95th percentile had a 6.8-fold increase (odds ratio (OR) = 6.75, 95% confidence interval (CI) 4.92–9.26; P = 2.84 × 10−32) in risk of developing TGCT compared to men at the 45–55th percentile. Dashed line indicates OR = 1; error bars represent 95% CI.
