Fig. 2: Recurrent structural and chromosomal alterations in NPC. | Nature Communications

Fig. 2: Recurrent structural and chromosomal alterations in NPC.

From: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Fig. 2

Circos plot showing recurrent SVs and common CNVs in NPC. Frequencies of copy number losses and gains are shown in the outer and inner circles respectively. Selected cancer genes involved in the recurrent inter- and intra-chromosomal SVs (i.e., genes with ≥3 times altered by SVs) are indicated. Homozygous deletions and structural alteration breakpoints identified in CDKN2A/B loci, MTAP, and cluster of type I IFN genes at 9p13.3, TGFBR2 at 3p24.1, and TRAF3 at 14q32.3 are shown. The DNA sequences spanning the breakpoints of deletion of TGFBR2 identified in NPC43 and Xeno-47 were confirmed by Sanger DNA sequencing.

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