Fig. 1: SARS-CoV-2-specific IFN-γ responses over 10 months post-infection. | Nature Communications

Fig. 1: SARS-CoV-2-specific IFN-γ responses over 10 months post-infection.

From: SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

Fig. 1

PBMC samples (n = 159) from individuals with SARS-CoV-2 infection (n = 87) and pre-pandemic PBMC samples (n = 8) from healthy donors (n = 8) were stimulated with OLPs of S, M, or N (1 μg/mL) for 24 h and the spot-forming units of IFN-γ-secreting cells examined by ELISpot. a Scatter plots showing the relationship between DPSO and IFN-γ responses. The black line is a LOESS smooth nonparametric function, and the gray shading represents the 95% confidence interval. b The composition of S-, M-, or N-specific IFN-γ responses among the total IFN-γ responses in each individual. c IFN-γ responses were compared between T1 (n = 49, 31–99 DPSO), T2 (n = 41, 100–199 DPSO), and T3 (n = 31, ≥200 DPSO). Data are presented as median and interquartile range (IQR). d, e IFN-γ responses were analyzed in longitudinally tracked samples (n = 103) from 39 individuals. d Scatter plots showing the relationship between DPSO and IFN-γ responses. e IFN-γ responses were compared between paired samples at two-time points (n = 15; t1, 31–100 DPSO; t2, ≥200 DPSO). Statistical analysis was performed using the two-sided Kruskal–Wallis test with Dunns’ multiple comparisons test (c) or the Wilcoxon signed-rank test (e). n.s, not significant.

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