Fig. 6: Knockdown of Epas1 in miR-455 KO knee cartilage rescues the abnormally increased expression of cartilage degeneration-related genes. | Nature Communications

Fig. 6: Knockdown of Epas1 in miR-455 KO knee cartilage rescues the abnormally increased expression of cartilage degeneration-related genes.

From: Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

Fig. 6

a Schedule of treatment using transfection of siRNA for Epas1 in knee cartilage of 6-month-old miR-455 knockout mice. The mouse figure is a partial modification of the figure created by Sho Mokuda in the previous paper65. b Relative expression levels of Epas1, Mmp3, Mmp13, Adamts5, and Nos2 in siRNA-transfected knee cartilage of 6-month-old wild-type (WT; n = 6, biologically independent samples) or miR-455 knockout mice (KO; n = 5, biologically independent samples). Data are represented as the mean ± SEM. Two-tailed Student’s t test. siCtrl: negative control siRNA, siEpas1: siRNA for Epas1. Source data are provided as a Source Data file.

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