Fig. 5: Time course of dyskinesia after gene transfer. | Nature Communications

Fig. 5: Time course of dyskinesia after gene transfer.

From: Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons

Fig. 5: Time course of dyskinesia after gene transfer.

Dyskinesia score, adapted from the Abnormal Involuntary Movement Scale (AIMS). Involuntary movements in each of 7 body regions were scored from 0 (none) to 4 (severe), for a maximum possible score of 28. A total score of 14 (dotted line) may correspond with either mild generalized dyskinesia, or moderate-severe involuntary movements in a more focal distribution. Dyskinesia peaked in severity between 1 and 3 months after surgery, and gradually improved thereafter. At Month 24, dyskinesia had resolved completely in all 3 subjects in Cohort 1.

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