Fig. 10: Toxicity studies. | Nature Communications

Fig. 10: Toxicity studies.

From: Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Fig. 10

Plasma levels of a AST, b ALT, c BUN, and d CREA after multi-dose injections of different drug formulations (1: PBS; 2: free Oxa; 3: Oxa(IV)@ZnPc; 4: Oxa(IV)@ZnPc@M; 5: BMMs; 6: Oxa(IV)@ZnPc@M + anti-PD-L1; and 7: BMMs + anti-PD-L1) (n = 4 individual animals). No significant difference of the treatment group compared with PBS group. e H&E staining of major organs after multi-dose injections, this experiment was performed two times with similar results. Scale bars = 200 µm. All data were presented as mean ± SD. Source data are provided as a Source data file.

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