Fig. 5: In vivo pharmacokinetics and tumor distribution. | Nature Communications

Fig. 5: In vivo pharmacokinetics and tumor distribution.

From: Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Fig. 5

a Pharmacokinetics profiles in SD rats after intravenous injection of free Oxa, Oxa(IV)@ZnPc and Oxa(IV)@ZnPc@M (n = 3 individual animals). b Fluorescence imaging of free ZnPc, Oxa(IV)@ZnPc and Oxa(IV)@ZnPc@M distribution in primary tumors and bone metastatic tumors in 4T1 tumor-bearing mice. Red circle represents tumor area. c Ex vivo fluorescence imaging of the excised organs and tumors at 24 h post-injection. d Quantitative fluorescence intensity of the excised organs and tumors at 24 h post-injection (n = 3 individual animals). e Quantification fluorescence intensity of primary tumors and bone metastatic tumors (**p = 0.0042, ***p = 0.0002, ***p < 0.0001, *p = 0.0259). f Quantification fluorescence intensity of tumor: liver at 24 h post-injection (***p = 0.0007, *p = 0.0461). Red circle represents tumor area. All data were presented as mean ± SD. Statistical significance was calculated via two-way ANOVA with a Tukey’s test. “ns” represents not significant, and *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source data file.

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