Fig. 3: Fingerprint grid plots.

a Prototypical fingerprint grid plot. Changes in blood transcript abundance for patients with Systemic Lupus Erythematosus (SLE) compared to healthy controls are represented on a fingerprint grid plot for this illustrative case. The modules occupy a fixed position on the fingerprint grid plots (see Fig. 2). An increase in transcript abundance for a given module is represented by a red spot; a decrease in abundance is represented by a blue spot. Modules arranged on a given row belong to a module aggregate (here denoted as A1 to A38). Changes measured at the “aggregate level” are represented by spots to the left of the grid next to the denomination for the corresponding aggregate. The colors and intensities of the spots are based on the average across each given row of modules. A module annotation grid is provided where a color key indicates the functional associations attributed to some of the modules on the grid (top right). Positions on the annotation grid occupied by modules for which no consensus annotation was attributed are colored white. Positions on the grid for which no modules have been assigned are colored gray. b–d Fingerprint grid plots for additional reference datasets (COPD: chronic obstructive pulmonary disease, HIV: human immunodeficiency virus).