Fig. 8: Literature profiles and patterns of changes in abundance across reference datasets for the modules comprising aggregate A28.

a Functional annotation by literature profiling. A. Portion of a heatmap comprising 382 modules organized as columns, and literature terms organized as rows. The six modules shown are associated with the consensus annotation “Interferon” or “Type 1 Interferon”. The clusters of keywords associated with those modules are consistent with this annotation and provide added granularity to the module repertoire for functional profiling and interpretation. b Changes in abundance across 16 reference datasets. The heatmap represents the changes in abundance of transcripts constituting the six modules comprising aggregate A28 (columns). The modules are functionally associated with interferon responses. The 16 reference datasets are arranged as rows corresponding to different health states. The columns and rows are arranged by hierarchical clustering. The heatmaps can be accessed and exported for all 16 datasets and 38 module aggregates using the web application: https://drinchai.shinyapps.io/BloodGen3Module/ (under the “MODULES X STUDIES” tab).