Fig. 5: Automated flow synthesis enables the rapid production of antisense PMO candidates to treat DMD.
From: Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
a Gene diagram showing the splicing sites where the three potential therapeutic sequences are targeted. Three sequences were chosen for targeting splice donor and acceptor sites of exon 46. b The mass spectrum, deconvoluted mass spectrum, and MALDI mass spectra of purified PMOs synthesized in flow are shown (see Supplementary section 13.4).
