Fig. 6: Allelic biased expression of IGF2 and INS-IGF2 in a human pancreatic islet sample. | Nature Communications

Fig. 6: Allelic biased expression of IGF2 and INS-IGF2 in a human pancreatic islet sample.

From: Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects

Fig. 6

The sequencing primer reads from the reverse strand in a–c, and from the forward strand in d. a Genotyping of rs2230949 from genomic DNA, locating inside the last exon of IGF2 gene. The locus is a G/A heterozygote. b Genotyping of rs2230949 of IGF2 isoform 1 transcript. Only the A allele is expressed, indicating that this is the paternal allele. c Genotyping of rs2230949 of INS-IGF2 isoform 1 transcript. The expression is biased toward the A allele. d Genotyping of rs689, showing that rs689 is the monoallelic T allele.

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