Fig. 1: C(sp3)–H functionalization of N-heterocycles.
From: Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
a Representative examples of N-heterocycles in pharmaceuticals and natural products. b Previously reported nitrogenous substrates of CDC reactions. c Previous work on organolithium promoted C–H α-functionalization of amines. d Previous work on Mn- or Fe-catalyzed C–H α-functionalization of amines. e This work: Cu-catalyzed C–H functionalization of N-heterocycles with NFSI or Selectflour II as oxidants and scope of N-heterocyclic substrates.
