Fig. 8: Structural remodeling upon cell fusion leads to endocytosis and AMPK-dependent YAP1 inhibition, which drives cell-cycle arrest and promotes a differentiated-like state. | Nature Communications

Fig. 8: Structural remodeling upon cell fusion leads to endocytosis and AMPK-dependent YAP1 inhibition, which drives cell-cycle arrest and promotes a differentiated-like state.

From: YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion

Fig. 8: Structural remodeling upon cell fusion leads to endocytosis and AMPK-dependent YAP1 inhibition, which drives cell-cycle arrest and promotes a differentiated-like state.

In proliferating cells, nuclear YAP1 promotes expression of genes to support the proliferative state. The acute structural remodeling upon cell fusion, including endocytosis of glucose transporters, causes transient changes in cell energetics (decreased cytoplasmic glucose and ATP) and AMPK activation that lead to persistent retention of YAP1 in the cytoplasm. As a result, fused cells exit the cell cycle and transcripts that promote cell differentiation are generated.

Back to article page