Table 3 Comparison of number and proportion of differentially methylated CpGs in various categories of CpGs.

From: A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer’s disease

 

# of positives in EWASplus predicted positives (%) total = 38

# of positive in on-array positives (%) total = 10

# of positives in EWASplus predicted negatives (%) total = 10

Any trait

25 (65.8)

6 (60.0)

3 (10.0)

Beta-amyloid

17 (44.7)

1 (10.0)

2 (20.0)

Braak staging

11 (28.9)

2 (20.0)

1 (10.0)

CERAD

17 (44.7)

2 (20.0)

3 (30.0)

Cognitive trajectory

7 (18.4)

3 (30.0)

0 (0.0)

Global pathology

13 (34.2)

2 (20.0)

3 (30.0)

Neurofibrillary tangles

16 (42.1)

5 (50.0)

1 (10.0)

  1. Methylation level is measured by targeted bisulfite sequencing experiment.