Fig. 3: Gene expression in the ALB-D2KO mouse liver.

a heat-map of liver RNA-seq data showing clustering of genes affected in the ALB-D2KO mouse; green indicates relative down-regulation; red indicates relative upregulation; fold change is shown on the left; most gene names are indicated on the right (nine samples were studied with no further replication); b browser IGV display of transcript areas of selected genes (eight representative genes out of a total of 146 genes) that are downregulated in the Alb-D2KO liver AND exhibit a RCA area within its core promoter region; the distance between the negative RNA-seq peak and the RCA area in all cases is < 5 Kbp; the gene names are indicated on the top of each panel along with the arrow indicating direction of transcription; the red tracks reflects the coverage for the Alb-D2KO Atac-seq and RNA-seq data, and the black tracks reflects the controls; the statistically significant RCA areas are indicated by a blue line.