Fig. 4: Interrelationship between H-sites and RCA areas in the ALB-D2KO mouse liver.

a correlation between the density (number of H-sites/size of the chromosome) of H-sites and promoter RCAs sites in each chromosome; the nonparametric Spearman r and the statistical significance are indicated; no adjustments were made for multiple comparisons [p < 0.0009 (two-tailed)]; b same as a, except that i-RCA sites were used [p < 0.0002 (two-tailed)]; c same as a, except that promoter RCAs and i-RCA sites were used [p < 0.0001 (two-tailed)]; d distance between H-sites and i-RCA areas vs. p-RCA areas; the number of H-sites and i-RCA areas at each distance bracket is indicated inside the circles; distances are indicated in Kbp; e same as c except that distances were calculated between intergenic RCA areas (i-RCA) vs. H-sites; there are 572 i-RCA located at a distance >1000 Kbp that are not indicated; f Circa representation of the 121 n-RNA-seq areas and p-RCA areas within 1000 bp of area-1 vs. the closest H-sites and i-RCA to area-2 areas across the Alb-D2KO liver genome; the outer most ring represents chromosome ideograms; on the right, the size of each chromosome is indicated in Mbp; the inner connecting lines indicate the Hi-C interacting points obtained from ref. ⁴³.