Fig. 10: Comparison of nitrate-functionalized cardiac patch with organic nitrates delivered by transdermal patch in terms of NO transformation pathway and therapeutic mechanism. | Nature Communications

Fig. 10: Comparison of nitrate-functionalized cardiac patch with organic nitrates delivered by transdermal patch in terms of NO transformation pathway and therapeutic mechanism.

From: Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery

Fig. 10: Comparison of nitrate-functionalized cardiac patch with organic nitrates delivered by transdermal patch in terms of NO transformation pathway and therapeutic mechanism.The alternative text for this image may have been generated using AI.

Left: Organic nitrates administrated by transdermal patch or other routes often release into the vasculature rapidly and transform to NO through intravascular metabolism. Due to the short half-life of NO the therapeutics is mainly based on hemodynamic effects through dilation of vascular smooth muscle. Right: Compared to small molecular organic nitrates, local NO delivery by nitrate-functionalized patches can further provide non-hemodynamic effects on the ischemic myocardium, including cardioprotection and immunomodulation.

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