Table 1 Neuroplasticity-related proteins regulated by stress-induced secretory autophagy.
From: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Protein | Fold change | Functions | Related mental disorders |
|---|---|---|---|
APP |
| Neuronal maturation, synaptogenesis, synapse remodeling, neurite outgrowth, synaptic activity, LTP | AD |
JUN | Detected in WT only | Neuronal differentiation and survival during development, post-traumatic repair, memory formation and addiction Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity | |
VIM |
| Neuroplasticity and neuroregeneration via uptake of C3bot | AD |
CDC42 |
| LTP, memory recall, neuronal maturation, synapse formation | |
MMP9 |
| Synaptic remodeling, extracellular cleavage of proteins regulating synaptic plasticity, late phase LTP, learning and memory | SCZ, FXS |
CCL2 |
| Spinal plasticity, short-term hippocampal synaptic plasticity, neuronal excitability and synaptic transmission via presynaptic mechanisms | AD, depression |
EEF2 |
| Synaptic plasticity, long term facilitation (LTF) and learning via local protein synthesis, key sensor for quality of neurotransmission; | |
HMGB1 |
| DAMP molecule, synaptic plasticity via inflammatory signaling | AD |
IGF1 |
| Hippocampal neurogenesis, social memory, LTP, age-related synaptic dysfunction | |
KDR | Detected in WT only | Neurogenesis and cognition mediated by environmental stimuli, hippocampal excitatory synaptic function, plasticity and related emotional learning processes, hippocampal LTP and consolidation of contextual fear memory | |
LRP1 |
| Neuroregeneration, conductance of neuronal ion channels, NMDA-induced Ca2 influx into neurons, neurotransmission, NMDAR2B expression at the cell surface, synaptic integrity and function via GluA1 trafficking regulation, APP processing | AD |
PAK1 | Detected in WT only | Inhibitory postsynaptic currents via GABA presynaptic releases, is regulated by cdc42 | AD, FXS, SCZ, HD |
PAK3 | Detected in WT only | Mental retardation protein, synaptic transmission | Intellectual disability |
STMN2 |
| Axonal remodeling via late phase LTP microtubule turnover and presynaptic remodeling | |
TF |
| AMPA receptor trafficking efficiency and synaptic plasticity via its receptor (TFR) | |
TGFB1 |
| Synapsin distribution, synaptic depression, neurite outgrowth, LTP and memory | |
CAT |
| LTP, learning and memory via regulation of ROS | Depression, PTSD |
HMOX1 |
| Neuronal cytokinetics, survival and plasticity via brain sterol/oxysterol metabolism regulation | AD, PD |
JUNB |
| GR/MR induced hippocampal plasticity (putative) Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity |
