Fig. 1: Genome-scale CRISPRi screen to identify prostate cancer-specific driver genes. | Nature Communications

Fig. 1: Genome-scale CRISPRi screen to identify prostate cancer-specific driver genes.

From: An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

Fig. 1: Genome-scale CRISPRi screen to identify prostate cancer-specific driver genes.

A Schematic of growth-based CRISPRi screens; B Correlation plot showing concordance between replicates of the CRISPRi screen in LNCaP cells (LNCaPi) at gene level; C Volcano plot showing Mann–Whitney statistical significance and average phenotype score of all genes and negative controls; D Filtering strategies implemented to identify genes that are specific to prostate cancer biology in the context of metastasis; E Competitive growth-based assay to validate top eight hits (n = 3 as biological replicates; Mean ± SEM).

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