Table 1 Summary of cohort information.

From: SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

SARS-CoV-2 RT-PCR+

Negative controls

 

n (%)

Children

Adults

P value

Children

Adults

 

Total donors

24

45

 

15

10

Age (mean ± stdev, range)

7.8 ± 3.9,

1.92–13 years

43 ± 4.0,

20–65 years

<0.0001

10.3 ± 3.2,

2–14 years

37.6 ± 13.0,

19–57 years

Female (%)

54% (13)

52% (23)

>0.9999

67% (10)

40% (4)

Symptom Severity

Asymptomatic

38% (9)

20% (9)

 

N/A

N/A

Mild/ Moderate

62% (15)

80% (36)

0.1523

N/A

N/A

Severe/ Critical

0%

0%

 

N/A

N/A

Sample time point information – days post symptom onset (n=, mean ± stdev, range)

 

All time points

n = 44

36 ± 38,

2−138 days

n = 75

29 ± 40,

1–180 days

0.262

N/A

N/A

Acute time points

n = 22

8 ± 3.8, 2–14 days

n = 44

8 ± 4.0, 1–14 days

0.949

N/A

N/A

Convalescent time points

n = 12

35 ± 10.9, 15–48 days

n = 19

26 ± 12.7, 15–53 days

0.074

N/A

N/A

Long-term memory time points (d > 60)

n = 8

103 ± 38.7, 89–138 days

n = 12

111 ± 35.8, 67–180 days

0.926

N/A

N/A

  1. NB: P values are calculated to compare adults and children using Fisher’s exact test to compare sex and symptom severity, and using Mann–Whitney to compare sample timepoint information.
  2. Samples from SARS-CoV-2 infected children and adults, and negative controls forming a cohort where samples were used in multiple cellular and ELISA assays.
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