Fig. 4: Structures of class III Nbs (17 and 36). | Nature Communications

Fig. 4: Structures of class III Nbs (17 and 36).

From: Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Fig. 4: Structures of class III Nbs (17 and 36).

a Cryo-EM structures of Nb17 in complex with S. b Nb17:RBD interactions are mediated by all three CDRs. c Cryo-EM structure of the Nb17:Nb105:RBD complex. d Nb17 structurally does not overlap with ACE2. e Cryo-EM structure of the Nb36:Nb21:RBD complex. f Epitope of Nb36 on the RBD surface. g Nb17 stacks on NTD via its framework, while isolated Nb36:RBD complex indicates Nb36 would clash with neighboring NTD on S. h ACE2 competition assay with the S.

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