Fig. 5: Class III Nbs bind semi-conserved epitopes unique to Nbs. | Nature Communications

Fig. 5: Class III Nbs bind semi-conserved epitopes unique to Nbs.

From: Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Fig. 5: Class III Nbs bind semi-conserved epitopes unique to Nbs.

a Epitope clustering analysis of RBD Nbs and correlation with RBD sequence conservation and ACE2 binding sites. The conservation scores of SARS-CoV-2 Spike RBD amino acids were computed by ConSurf server using the empirical Bayesian method from the multiple sequence alignment and normalized by the z-score method. b Overview of three Nb classes binding to the RBD, RBD surface was colored based on conservation (ConSurf score). c–e. Structural comparison of different classes of Nbs with the closest mAbs for RBD binding.

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