Fig. 7: Ingenuity Pathway Analysis (IPA) analysis of MR and GR ChIP-Seq data. | Nature Communications

Fig. 7: Ingenuity Pathway Analysis (IPA) analysis of MR and GR ChIP-Seq data.

From: Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Fig. 7: Ingenuity Pathway Analysis (IPA) analysis of MR and GR ChIP-Seq data.The alt text for this image may have been generated using AI.

IPA analysis was conducted on MR and GR ChIP-Seq FS30 (a, c, e, g, i) and BLPM (b, d, f, h, j) data sets at FDR ≤ 0.1. The graphs represent pathways significantly associated with differentially bound MR- and GR-binding genes (dark blue and light blue bars, respectively) for top terms relating to Cell Morphology (a, b), Cell to Cell Signalling (c, d), Cell Development and Movement (e, f), Behavior (g, h), and Neuropsychiatric Diseases (i, j). The number of genes within the dataset relating to each term is provided next to the corresponding bar. The Z-score was determined to infer the activation state of the gene within the molecular network. Z-scores of >+2 indicate that the gene is considered significantly activating within the network, whereas scores of <-2 are regarded as significantly inhibiting. Source data are provided in the Source Data File.

Back to article page