Fig. 6: V. cholerae turns on FruT in response to O₂ for growth in seawater.

a qRT-PCR expression level of fruI and fruT in the mouse small intestine and seawater under aerobic conditions. Data represent the mean ± SD (n = 3). b Competition assay comparing the survival ability of WT and ΔfruT within a membrane-enclosed environment in seawater that was replaced by fresh seawater every 6 h under aerobic conditions. c, d Competition assay comparing the survival ability of WT and ΔfruT located within a membrane-enclosed environment in artificial seawater medium that was supplemented with 0.1 μM fructose (c) or 0.1 μM glucose (d) as the only carbon source every 6 h under aerobic conditions. e Competition assay comparing the survival ability of WT and ΔfruT located within a membrane-enclosed environment in artificial seawater medium that was supplemented with 0.1 μM fructose under anaerobic conditions. CI was determined as the output ratio of ΔfruT to WT lacZ- cells divided by the input ratio of ΔfruT to WT lacZ- cells. Data represent the mean ± SD (n = 3). Significance is determined by two-tailed unpaired Student’s t test (a) and indicated as the P value; n.s. means no significant difference. Source data are included in Source Data file.