Fig. 8: Model of type I IFN-mediated effects of IFITM3.
From: Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
During viral infection, IFITM3 decreases proteolysis of virus capsid proteins, and restricts fusion and entry into the cytosol. During Lm infection, IFITM3-mediated suppression of proteolysis leads to increased LLO and ActA in the phagosome. After entering the cytosol, increased actin recruitment subsequently leads to an increase in cell-to-cell spread. Arrows indicate decrease (red) or increase (green) by IFITM3.
