Fig. 4: Comparative analysis of CLL with a healthy donor. | Nature Communications

Fig. 4: Comparative analysis of CLL with a healthy donor.

From: Sc-compReg enables the comparison of gene regulatory networks between conditions using single-cell data

Fig. 4

A tSNE plots colored with clustering label for scRNA-seq (left) and scATAC-seq (right) on CLL donor. B Cluster mapping between the healthy donor and the CLL donor. We find nine linked subpopulations based on our profile-based pairing method. The label in the bracket represents dominant surrogate ground truths. The result from profile-based pairing is completely consistent with the surrogate ground truths-based mapping. Please see “Linking of subpopulations across conditions” in the “Methods” section. C The fraction of cell types in healthy donor and CLL donor based on the constructed true labels. D Clustering of B cell subpopulation based on the joint pattern of markers CD19, CD23, and CD69. The numbers represent the Hellinger distance.

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