Fig. 1: Metabolic pathways driving the ferroptosis-susceptible state in response to cystine starvation in cancer cells. | Nature Communications

Fig. 1: Metabolic pathways driving the ferroptosis-susceptible state in response to cystine starvation in cancer cells.

From: Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Fig. 1

GSH glutathione (reduced), GPX4 glutathione peroxidase 4, GCLC glutamate-cysteine ligase catalytic subunit, GSS glutathione synthetase, TFRC transferrin receptor, NFS1 cysteine desulfurase, Fe–S cluster iron–sulfur cluster, ROS reactive oxygen species, CoA co-enzyme A, PANK pantothenate kinases, 4EBP1 eukaryotic translation initiation factor 4E binding protein 1.

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