Table 3 Morphometric and echocardiographic characteristics of mice subjected to sham or MI surgery and treated for 3 weeks with AAV9-MCS or AAV9-miR-106b~25.

n

8

8

8

8

BW (g)

22.8 ± 2.1

25.3 ± 2.0

23.8 ± 1.5

24.3 ± 1.7

LV mass (mg)

84 ± 3

90 ± 2

88 ± 5

107 ± 4*^#

LV mass/BW (mg/g)

3.2 ± 0.2

3.8 ± 0.4

5.2 ± 0.4*

6.4 ± 1.0*

IVSd (mm)

0.79 ± 0.03

0.81 ± 0.02

0.75 ± 0.03

0.90 ± 0.03*^#

IVSs (mm)

1.18 ± 0.05

1.23 ± 0.07

1.10 ± 0.04

1.40 ± 0.06*^#

LVIDd (mm)

3.62 ± 0.07

3.78 ± 0.10

4.53 ± 0.19*

4.00 ± 0.02^#

LVIDs (mm)

2.42 ± 0.13

2.56 ± 0.14

3.55 ± 0.20*

2.79 ± 0.26^#

LVPWd (mm)

0.88 ± 0.03

0.86 ± 0.05

0.55 ± 0.05*

0.87 ± 0.10^#

LVPWs (mm)

1.16 ± 0.05

1.21 ± 0.06

0.69 ± 0.07*

1.05 ± 0.13^#

EF (%)

69 ± 4

67 ± 3

52 ± 2*

65 ± 4*^#

FS (%)

33 ± 3

31 ± 2

22 ± 1*

31 ± 3*^#