Fig. 3: Scope of alkyl amines. | Nature Communications

Fig. 3: Scope of alkyl amines.

From: Nickel-catalyzed deaminative Sonogashira coupling of alkylpyridinium salts enabled by NN2 pincer ligand

Fig. 3

a Scope of primary alkylpyridinium salts. b Scope of benzylpyridinium salts. c Scope of secondary alkylpyridinium salts. d Scope of amino acid and peptide-derived pyridinium salts. Reaction conditions: 1 (0.3 mmol), 2a (0.45 mmol), NiCl2·6H2O (10 mol%), L4 (10 mol%), K3PO4 (1.3 equiv), THF (1.5 mL), 80 °C. Isolated yields. For 4g, 4h, 4p, 4q, 4r, 4s, 4t, 4u, 4v, 4w, 4y, 4z, and 4aa, reactions were conducted in DMF (1.5 mL). For 4m, 4n, and 4o, reactions were conducted at 50 °C.

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