Fig. 2: Summary of the datasets included in this analysis.

a Datasets collectively represent a diverse set of expression methods, experiment durations, species, selection types, gRNA library sizes, and target types. The bars on some data points represent the range of days that activity in those datasets has been calculated from. b–z These datasets cover a broad range of activity distributions, including moderate to extremely binary distributions, normal distributions, and completely uniform distributions, based on how activity was measured and data were processed. All datasets are shown with higher gRNA activity represented by larger numbers. In some cases, that required inverting the scale of activity as described in the Methods (namely, b, d, o, w, x, and y).