Fig. 4: Differences in cortico-STN and cortico-GPi coherence for the Shanghai cohort; high beta band coherence segregates to the cortico-STN network.

As per Fig. 2 panels A–C are SPMs showing results of the 2 × 2 ANOVA with factors frequency (low beta versus high beta) and target nucleus (STN versus GPi). A The upper panel displays regions where there was a significant main effect of the band, such that cortical coherence with both the STN and GPi was greater at high rather than at low beta frequencies. The cluster encompasses the SMA. Cross-hairs are centered on the location of the peak t-statistic at 2 -2 76. In the lower panel, the cross-hairs are centered at the location of the hand area of the primary motor cortex, highlighting that the main effect was centered medially. B A cluster displaying a significant main effect of site, such that coherence across the high and low beta bands was greater for the STN than for the GPi, is shown. The cluster includes the mesial primary motor cortex and the cross-hairs are centered on the location of the peak t-statistic at MNI coordinates 8 -52 82. C A cluster lying within the SMA, for which there was a simple main effect of the band for the STN is displayed. The cross-hairs are centered on the peak t-statistic location at MNI coordinates 2 -16 54. Panels D and E show group mean (with standard errors) and individual coherence spectra computed between the STN/GPi and cortical locations of the peak t-statistic separately for the main effect of the band (D) and site (E). These correspond to the clusters in A and B which are located in the SMA and in the mesial primary motor cortex (M1).