Fig. 5: Interactions at the TRBV5-1+ TCR-HLA-DQ8-HIPL11C interface.
From: T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
a Conserved interactions between TRBV5-1+ TCR CDRβ loops; β-framework and the HLA-DQ8 α-chain using TCR A1.9 as an example. The HLA-DQ8 α-chain is coloured in neon. Whilst the CDR1β, CDR2β, CDR3β loops and β-framework are in gold, magenta, blue, and green, respectively. b–d The CDR loops of A3.10, A1.9 and A2.13 TCRs make conserved contacts with the HIPL11C peptide. The CDR1α and CDR3α loops are coloured in red and pink, respectively, and the CDRβ loops colours as described above. The HIPL11C peptide is coloured such that the C-peptide fragment is in lime-green and the IAPP2 fragment in orange. Hydrogen bonds (H-bonds) are denoted as black dashed lines, whilst vdW interactions are presented as orange dashed lines. Cartoon representations of the interactions between the CDR loop and HLA-DQ8-HIPL11C are shown with oxygen atoms in red and nitrogen atoms in blue.
