Table 1 TCR gene usage of CD4 + HLA-DQ8-HIPL11C tetramer+ T cells in T1D patients ET600, ET650, and ET672 PBMC.
From: T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Clone | TRAV | TRAJ | CDR1α | CDR2α | CDR3α | TRBV | TRBJ | TRBD | CDR1β | CDR2β | CDR3β | No. clone |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ET600-1 | 26-1 | 33*01 | TISGNEY | GLKN | CIVRDSNYQLIW | 29-1 | 1-2*01 | 1*01 | SQVTM | ANQGSEA | CSANRDGGGYTF | 7 |
ET600-2 | 8-3 | 22*01 | YGATPY | YFSGDTL | CAVGGTSGSARQLTF | 10-3 | 1-2*01 | 2*01 | ENHRY | SYGVKD | CAISEGERGSNYGYTF | 6 |
ET600-3 | 8-3 | 27*01 | YGATPY | YFSGDTL | CAVGFNAGKSTF | 5-1 | 1-1*01 | 1*01 | SGHRS | YFSETQ | CASSLGPTGTNTEAFF | 1 |
ET600-4 | 14/DV4 | 39*01 | TSDPSYG | QGSYDQQ | CAMRPNNAGNMLTF | 15 | 1-5*01 | 1*01 | LNHNV | YYDKDF | CATSRGNQGPNQPQHF | 1 |
ET600-5 | 26-1 | 39*01 | TISGNEY | GLKN | CIVRVNNAGNMLTF | 28 | 1-2*01 | 2*01 | MDHEN | SYDVKM | CASSRLDNGYTF | 1 |
ET600-6 | 12-2 | 15*01 | DRGSQS | IYSNG | CAVNQAGTALIF | 11-1 | 2-1*01 | 1*01 | SGHAT | FQDESV | CASSWAYNEQFF | 1 |
ET600-7 | 3 | 6*01 | VSGNPY | YITGDNLV | CAVRDGGSYIPTF | 7-8 | 2-7*01 | 1*01 | SGHVS | FQNEAQ | CASSLLPDRGHEQYF | 1 |
ET600-8 | 19 | 9*01 | TRDTTYY | RNSFDEQ | CALSEVNTGGFKTIF | 10-3 | 2-6*01 | 1*01 | ENHRY | SYGVKD | CAISLQGSRSGANVLTF | 1 |
ET650-1 | 26-1 | 54*01 | TISGNEY | GLKN | CIVRVEIQGAQKLVF | 5-1 | 2-5*01 | 1*01 | SGHRS | YFSETQ | CASSLGPGLRETQYF | 4 |
ET650-2 | 26-1 | 39*01 | TISGNEY | GLKN | CIVRVGYNAGNMLTF | 20-1 | 1-5*01 | 2*01 | DFQETT | SNEGSKA | CSAIAGPNQPQHF | 3 |
ET650-3 | 26-1 | 42*01 | TISGNEY | GLKN | CIVRPQKGGSQGNLIF | 3-1 | 2-3*01 | LGHDT | YNNKEL | CASSHHSTDTQYF | 2 | |
ET650-4 | 26-1 | 42*01 | TISGNEY | GLKN | CIVRVAIEGSQGNLIF | 5-1 | 1-3*01 | 1*01 | SGHRS | YFSETQ | CASSLRRGDTIYF | 1 |
ET650-5 | 26-1 | 9*01 | TISGNEY | GLKN | CIVRLQSGGFKTIF | 20-1 | 1-2*01 | 1*01 | DFQETT | SNEGSKA | CSAYSPGDRDFSNYGYTF | 1 |
ET650-6 | 39 | 54*01 | TTSDR | LLSNGAV | CAVDIQGAQKLVF | 7-8 | 2-3*01 | 1*01 | SGHVS | FQNEAQ | CASSLRTAISRTDTQYF | 1 |
ET650-7 | 30 | 48*01 | KALYS | LLKGGEQ | CGTLAFGNEKLTF | 19 | 1-6*01 | 2*01 | LNHDA | SQIVND | CASHRGKGNSPLHF | 1 |
ET650-8 | 35 | 49*01 | SIFNT | LYKAGEL | CAGQLWNTGNQFYF | 11-1 | 2-3*01 | 2*01 | SGHAT | FQDESV | SHLRGASTDTQ | 1 |
ET672-1 | 12-2 | 48*01 | DRGSQS | IYSNGD | CAVNHGNEKLTF | 18 | 1-1*01 | 1*01 | KGHSH | LQKENI | CASSPWEGRMDTEAFF | 18 |
ET672-2 | 12-1 | 37*02 | NSASQS | VYSSGN | CVVVSNTGKLIF | 23-1 | 2-1*01 | 2*01 | KGHTF | FQNEQV | CASSQWVSGEDEQFF | 1 |
